全文获取类型
收费全文 | 1292篇 |
免费 | 127篇 |
国内免费 | 65篇 |
出版年
2024年 | 1篇 |
2023年 | 43篇 |
2022年 | 40篇 |
2021年 | 89篇 |
2020年 | 77篇 |
2019年 | 92篇 |
2018年 | 77篇 |
2017年 | 66篇 |
2016年 | 77篇 |
2015年 | 81篇 |
2014年 | 104篇 |
2013年 | 152篇 |
2012年 | 62篇 |
2011年 | 84篇 |
2010年 | 53篇 |
2009年 | 41篇 |
2008年 | 29篇 |
2007年 | 49篇 |
2006年 | 39篇 |
2005年 | 35篇 |
2004年 | 21篇 |
2003年 | 24篇 |
2002年 | 17篇 |
2001年 | 25篇 |
2000年 | 17篇 |
1999年 | 10篇 |
1998年 | 7篇 |
1997年 | 10篇 |
1996年 | 9篇 |
1995年 | 10篇 |
1994年 | 5篇 |
1993年 | 6篇 |
1992年 | 1篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1986年 | 1篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有1484条查询结果,搜索用时 15 毫秒
1.
Weaponizing Principles: Clinical Ethics Consultations & the Plight of the Morally Vulnerable 下载免费PDF全文
Autumn M. Fiester 《Bioethics》2015,29(5):309-315
Internationally, there is an on‐going dialogue about how to professionalize ethics consultation services (ECSs). Despite these efforts, one aspect of ECS‐competence that has received scant attention is the liability of failing to adequately capture all of the relevant moral considerations in an ethics conflict. This failure carries a high price for the least powerful stakeholders in the dispute. When an ECS does not possess a sophisticated dexterity at translating what stakeholders say in a conflict into ethical concepts or principles, it runs the risk of naming one side's claims as morally legitimate and decrying the other's as merely self‐serving. The result of this failure is that one side in a dispute is granted significantly more moral weight and authority than the other. The remedy to this problem is that ECSs learn how to expand the diagnostic moral lens they employ in clinical ethics conflicts. 相似文献
2.
3.
G Perretta A Violante M Scarpulla M Beciani V Monaco 《Journal of medical primatology》1991,20(7):345-351
The effects of age, sex, pregnancy, were analyzed and data from fasted and fed animals were compared in a population of cynomolgus macaques. No significant sex effects were observed for biochemical values and no changes were found in male hematological parameters in relation to age. Most values of females during pregnancy were within normal ranges. Comparison between fed and fasted animals showed that several biochemical parameters (e.g., ALT, glucose, CPK, LDH) and several hematological parameters (e.g., monocytes, eosinophils, basophils, hemoglobin, MCV, MCHC, and MCH) were affected by food intake. 相似文献
4.
5.
Douglas Sipp 《Journal of cellular biochemistry》2009,107(5):853-856
Stem cell research stands as a high‐priority field in many countries across the Asia‐Pacific region, and the past decade has seen remarkable investment into facilities and programs intended to increase competitiveness in the drive to find clinical applications. In the years roughly framed by Korean cloner Woo‐Suk Hwang's meteoric ascent and fall, speculation was rampant that Asia was poised to overtake the West in this field of science. But that potential remains unfulfilled. In this article, I will look at some of the deficits in infrastructure and governance that underlie the East–West stem cell gap, and suggest a number of measures that might be taken to remedy them. J. Cell. Biochem. 107: 853–856, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
6.
Tests for no treatment effect in randomized clinical trials 总被引:1,自引:0,他引:1
7.
Nataly Mancette Rijensky Netta R. Blondheim Shraga Eilon Barnea Nir Peled Eli Rosenbaum Aron Popovtzer Solomon M. Stemmer Alejandro Livoff Mark Shlapobersky Neta Moskovits Dafna Perry Eitan Rubin Itzhak Haviv Arie Admon 《Molecular & cellular proteomics : MCP》2020,19(8):1360-1374
Highlights
- •Sufficient tumor tissues are often unavailable large HLA peptidome discovery.
- •Using patient derived xenograft (PDX) tumors can overcome this limitation.
- •The large PDX HLA peptidomes expand significantly those of the original biopsies.
- •The HLA peptidomes of the PDX tumors included many tumor antigens.
8.
zge Karayel Francesca Tonelli Sebastian Virreira Winter Phillip E. Geyer Ying Fan Esther M. Sammler Dario R. Alessi Martin Steger Matthias Mann 《Molecular & cellular proteomics : MCP》2020,19(9):1546-1560
Highlights
- •MS-based clinical assay that accurately determines phospho Rab10 occupancy.
- •Stable isotope labeled phosphopeptide injected as a standard with endogenous tryptic phospho Rab peptide for accurate ratio determination.
- •Determination of pRab levels in neutrophils of Parkinson disease patients.
- •Relevance of pRab levels as marker of PD.
9.
Translational research using evidence-based and comparative effectiveness research continues to evolve, becoming a useful tool in improving informed
consent and decision-making in the clinical setting. While in development, emerging technologies, including cellular and molecular biology, are leading to
establishing evidence-based dental practices. One emerging technology, which conjoins bench proteomic findings to clinical decision-making for
treatment intervention, is the Translational Evidence Mechanism. This mechanism was developed to be a foundation for a compact between researcher,
translational researcher, clinician, and patient. The output of such a mechanism is the clinical practice guideline (CPG), an interactive tool for dentists and
patients to game evidence in reaching optimum clinical decisions that correspond to individual patient preferences and values. As such, the clinical
practice guideline requires the vesting of decision, utility, and cost best evidence. Evidence-based research provides decision data, a first attempt at
supporting decision-making by providing best outcome data. Since then comparative effectiveness research has emerged, using systematic review analysis
to compare similar treatments or procedures in maximizing the choice of the most effective cost/benefit option within the context of best evidence. With
innovation in the clinical practice guideline for optimizing efficacy and comparative effectiveness research, evidence-based practices will shape a new
approach to health-based systems that adhere to shared decision-making between bench scientists, healthcare providers and patients. 相似文献
10.
《Biotechnic & histochemistry》2013,88(7):388-396
AbstractMicroRNAs (miRNAs) are endogenously produced non-coding RNAs that serve as micromanagers by negatively regulating gene expression. MiRNAs are implicated in several biological pathways including development of neoplasia. Because altered miRNA expression is implicated in the pathobiology of various cancers, these molecules serve as potential therapeutic targets. Using miRNA mimics to restore levels of aberrantly down-regulated miRNAs or miRNA inhibitors to inactivate over-expressed miRNAs shows promise as the next generation of therapeutic strategies. Manipulation of miRNAs offers an alternative therapeutic approach for chemo- and radiation-resistant tumors. Similarly, miRNA expression patterns can be used for diagnosis and to predict prognosis and efficacy of therapy. We present here an overview of how miRNAs affect cancers, how they may be used as biomarkers, and the clinical implications of miRNAs in cancer. 相似文献